新霉素 B 硫酸盐
新霉素 B 硫酸盐(Framycetin sulphate)
CAS: 4146-30-9
化学式: C23H48N6O17S
| 中文名 | 新霉素 B 硫酸盐 |
| 英文名 | Framycetin sulphate |
| 别名 | 硫酸弗兰西汀 新霉素 B 硫酸盐 硫酸新霉素B EP标准品 硫酸新霉素B(硫酸弗兰西汀) 新霉素B硫酸盐[硫酸弗拉菌素] (2S,3S,4R,5R,6R)-5-氨基-2-(氨基甲基)-6-(((2R,3S,4R,5S)-5-(((1R,2R,3S,5R,6S)-3,5-二氨基-2-(((2R,3R,4R,5S,6R)-3-氨基-6-(氨基甲基)-4,5-二羟基四氢-2H-吡喃-2-基)氧基)-6-羟基环己基)氧基)-4-羟基-2-(羟甲基)四氢呋喃-3-基)氧基)四氢-2H-吡喃-3,4-二醇三(硫酸盐) |
| 英文别名 | NeomycinBsulfate Framycetin Sulfate Framycetin sulphate Neomycin sulphate B neomycin B trisulfate NEOMYCIN SULPHATE B(FRAMYCETIN SULPHATE) (2R,3S,4R,5R,6R)-5-Amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2R,3R,4S,5R)-4-[(2S,3S,4S,5R,6R)-3-amino-6-(aminomethyl)-4,5-dihydroxy-oxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxy-cyclohexyl]oxy-oxane-3,4-diol sulphate |
| CAS | 4146-30-9 |
| EINECS | 223-969-3 |
| 化学式 | C23H48N6O17S |
| 分子量 | 712.72 |
| 熔点 | >160°C (dec.) |
| 溶解度 | 易溶于水，极微溶于醇，几乎不溶于丙酮。 |
| 存储条件 | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| 稳定性 | 吸湿性 |
| 外观 | 固体 |
| 颜色 | White to Off-White |
| 体外研究 | The inhibition of RNase P RNA cleavage by Framycetin sulfate (Neomycin Bsulfate; Fradiomycin Bsulfate) is sensitive to pH and an increase in pH suppresses the inhibition in other systems. Framycetin sulfate targets the bacterial and human ribosome and affect translation. 5″-azido neomycin B and Framycetin sulfate selectively inhibit production of the mature miRNA, boosts a downstream protein, and inhibits invasion in HCC cell line. Framycetin sulfate binds to a structural rather than a sequence motif of the RNA. Its primary cognate target is the decoding site of the 16S rRNA, but it also binds to the Rev-responsive element in HIV-1, group I introns, and the hammerhead ribozyme, and thus inhibits their biological function. Framycetin sulfate induces misreading of the genetic code during translation and inhibits several ribozymes. The ribosomal target site is the 16 S rRNA 1400 to 1500 region. |
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